Thrombotic thrombocytopenic purpura is a life-threatening disorder of extensive thrombosis in the microvasculature that manifests as systemic thrombosis and affects organ blood supply. Clinical fever and bleeding, renal impairment, and neurologic changes are often present. The disease is generally more serious.
Thrombotic thrombocytopenic purpura is a serious and rare disease with a rapid onset and high mortality requiring urgent treatment, and is mainly associated with abnormalities in vascular hemophilic factor (vWF) protein cleaving enzymes.
Treatment of thrombotic thrombocytopenic purpura includes plasmapheresis, fresh frozen plasma transfusion. Glucocorticoids such as methylprednisolone and dexamethasone may be used adjunctively, and immunoglobulin may be administered intravenously in patients who have had ineffective plasma exchange or multiple relapses.
When the disease is suspected or diagnosed, it should be consulted as soon as possible in order to prolong survival, reduce complications and improve the quality of life. All of the above drugs should be used in accordance with medical advice.