Antihistamine medications are more effective in treating hives. The causes of urticaria are related to food, drugs, infection, physical factors, environmental changes and other factors. It mainly manifests as windy masses and red spots with itching and other symptoms. Antihistamines are preferred for the treatment of urticaria, including loratadine, cetirizine, ibastine, fexofenadine and so on. The drugs can reduce the release of histamine in the skin when taken, which can effectively relieve itching. Therefore, it is useful to take antihistamines for hives. If hives occur frequently, it is recommended to find the cause or trigger and eliminate it, which can reduce the recurrence of hives. When giving antihistamines is not effective, it can be combined with drugs such as hydroxychloroquine and tretinoin to regulate the immune system and relieve symptoms. Frequent itchy skin, erythema, wind masses and other manifestations, it is recommended to promptly go to the hospital dermatology department, under the guidance of the doctor to use medication.