Oncological chemotherapy refers to the application of chemical drugs (including endocrine drugs) to treat drugs. The development history of chemotherapy is relatively short. 1942, Gilman, Goodman and Lindskog of Yale University first used nitrogen mustard to treat malignant tumors of lymphatic system, which is considered as the beginning of modern chemotherapy for tumors. 60s later, countries strengthened the research of anti-cancer drug screening, so that new effective anti-cancer drugs appeared continuously. At present, chemotherapy alone is still at the level of palliative treatment for many tumors, but for certain tumors with high malignancy, poor differentiation, easy to disseminate distantly and systemic, such as choriocarcinoma, acute lymphoblastic leukemia, testicular tumor and malignant lymphoma, chemotherapy has achieved a fairly high cure rate. For breast cancer, osteosarcoma, soft tissue sarcoma and colorectal cancer postoperative adjuvant chemotherapy can improve the cure rate, but also see the most common clinical solid tumors, such as liver cancer, non-small cell lung cancer, gastrointestinal cancer and pancreatic cancer, the current efficacy of chemotherapy is not satisfactory.