Refractory epilepsy requires standardized and regular medication despite poor response to medication, but pseudo-refractory epilepsy due to incorrect medication should be excluded. For epilepsy refractory to first-line drugs (carbamazepine, sodium valproate, etc.), new antiepileptic (oxcarbazepine, levetiracetam, lamotrigine, etc.) drugs can be prescribed under the guidance of a physician, and some patients will respond to new antiepileptic drugs; for epilepsy in which even new antiepileptic drugs do not work, even if surgery is considered, the original treatment should be maintained before surgery to prevent irregular medication from making the originally frequent The seizures will increase and create unexpected situations.