Heartburn, chest tightness and difficulty in breathing may be caused by the following diseases: 1. Arrhythmia: When arrhythmia occurs, patients will have panic as the main symptom, including tachycardia, bradycardia, premature beats, atrial fibrillation and other diseases. Bradycardia and tachycardia are physiologically and pathologically differentiated, and premature beats are classified as ventricular, atrial and supraventricular. A part of patients with atrial fibrillation can also show panic, chest tightness and difficulty in breathing, at this time, an electrocardiogram or 24-hour ambulatory ECG monitoring should be done to clarify the specific diagnosis. 2. Insufficient blood supply to the heart: some patients with coronary artery disease and angina pectoris will show the above symptoms, at this time, a coronary angiogram or coronary CT is needed to improve the examination. 3. Heart failure: when the heart function decreases, the heart enlarges and the ejection fraction 4.Pulmonary disease: Some patients with pulmonary disease will also have difficulty breathing, with chest tightness and panic, and need to do CT of the lungs to clarify the diagnosis, including lung infection, lung occupancy and other diseases.