Subcutaneous lipoma and acne are both benign diseases with the main difference being in the cause and clinical manifestations. 1. Sebaceous cysts, also known as acne, are skin appendages in which the glandular opening or excretory duct of sebaceous cysts is blocked by trauma, infection or follicular keratinization, resulting in sebum stasis during the period of sebaceous stagnation and the formation of a retention cyst. It is prone to secondary infection and may become malignant. It can occur at any age and is more common in adults. Prevalent in the head, face, buttocks, and back. The main symptom is an intradermal swelling, painless, about 1-3cm in size, well defined and slightly elevated. The treatment is mainly surgical excision, and if it is infected, it needs anti-infection treatment and surgery. 2. Subcutaneous lipoma is a benign tumor composed of adipose tissue, which can occur in any part of the body. The body surface lipoma is located under the skin in the form of round, flat round, irregular round lobulated nodules. Lipoma has no malignant tendency. They can be single or multiple, and vary in size and number from 1-10cm. Treatment: Surgical resection is needed if there is pain or if the tumor is large. Clinically, if you find subcutaneous swelling, you need to go to the hospital in time to let the doctor to check, and then according to the patient’s specific situation to determine the treatment.