Epilepsy can have a fixed mode of inheritance or a certain genetic predisposition, with some not inherited. Clinically, there are primary and secondary epilepsies, where primary epilepsy refers to epilepsy that does not have an underlying cause other than genetic factors, has a genetic predisposition, and the risk of the next generation having epilepsy is about 2-5%. Some inherited metabolic disorders have epilepsy as their main manifestation, and these disorders are inherited according to a specific genetic pattern such as autosomal dominant, autosomal recessive, or matrilineal. In contrast, epilepsy caused by secondary factors, such as hypoxia, intracranial tumors, encephalitis, and other diseases that cause epilepsy, is not inherited. For the genetic predisposition of epilepsy, the type of epilepsy and the cause of the seizures should be clarified first. Primary epilepsy is associated with genetic factors, and the closer the blood relationship, the higher the chance of heredity. To reduce the chance of inheritance of epilepsy, patients with epilepsy should treat epilepsy effectively and timely under the guidance of professional doctors, and have offspring after curing epilepsy, which can effectively reduce the chance of inheriting epilepsy in offspring. In addition, good premarital examination. Studies have shown that when both parents have epilepsy, the chances of the child developing epilepsy are greater than if the child is inherited unilaterally. Therefore, people with epilepsy should try to avoid marrying someone with epilepsy of the opposite sex.