Hyperinsulinemia is defined as fasting insulin ≥ 85 pmol/L. The biological role of insulin is weakened in hypertensive patients by hypertension or obesity. In this case, the human body becomes resistant to insulin, and in order to maintain a more normal blood glucose level, their body’s self-regulatory mechanism causes their pancreatic beta cells to secrete several times or even a dozen times more insulin than normal to lower blood glucose, which results in hyperinsulinemia. Low insulin levels indicate islet failure, but some patients do not properly understand that high insulin levels are a good thing, but they are not. Hyperinsulinemia is the common basis for the development of coronary heart disease, hypertension, hyperlipidemia, type II diabetes, obesity and stroke. Instead of lowering blood glucose, high insulin levels can harm the innocent heart and vascular system. In healthy or pre-diabetic individuals, hyperinsulinemia can lead to the development of diabetes, and in diabetic patients, hyperinsulinemia results in microangiopathy, such as fundus and kidney problems. Hyperinsulinemia is not due to the islet cells working “aggressively”, but to the insensitivity of the surrounding tissues to insulin. In order to maintain normal blood glucose levels, the islet cells work “hard” to secrete insulin, which results in high insulin in the plasma, and the large amount of insulin causes fat cell hyperplasia. The cardiovascular risk of hyperinsulinemia The insensitivity of peripheral tissues to insulin reduces the effect of insulin in muscle and inhibits the lipolytic effect of adipose tissue. Insulin resistance in adipose tissue leads to increased blood free fatty acid and triglyceride concentrations. High triglycerides and LDL increase the risk of cardiovascular disease. LDL can penetrate the intima of coronary arteries and other arteries, forming atherosclerotic plaques and blocking blood vessels. Heart and cerebrovascular disease can occur earlier in diabetics with combined dyslipidemia, especially in women. Estrogen in women protects the heart and blood vessels, and diabetes takes away the protective effect of estrogen. Hyperinsulinemia also damages the endothelial cells of blood vessels, causing platelet aggregation and making blood prone to clotting. Insulin likewise activates the sympathetic nervous system in insulin-resistant patients, causing vasospasm and increased resistance, contributing to the development of essential hypertension. At the same time, the heart can also be affected, causing abnormalities in the ventricular structure, reduced heart function or even failure. The relationship between hyperinsulinemia and heart disease was noted by the medical community as early as 1988, when this type of metabolic abnormality was known as syndrome X. By the 2l century, syndrome X was officially renamed metabolic syndrome. The metabolic syndrome includes abnormal blood sugar, hypertension, obesity or central obesity, and dyslipidemia. Treatment of hyperinsulinemia 1. Enhance physical exercise: Physical activity can increase tissue sensitivity to insulin, reduce body weight, improve metabolism, reduce insulin resistance, bring relief to hyperinsulinemia and reduce cardiovascular complications. 2, improve the diet structure: Whether in China or in the West, people’s diet structure is mainly high calorie and high fat. The calorie intake exceeds the consumption, which causes the accumulation of fat in the body to cause obesity. Therefore, the diet should be diversified to maintain nutritional balance and avoid excess nutrition. 3, drug treatment: the disease to drug treatment, must be under the guidance of doctors. Take medication while monitoring in order to regulate the hormone level to within the healthy index. Attachment: normal value of insulin fasting 4.03-23.46 pmol/ml, half hour 22.63-137.52 pmol/ml, one hour 21.73-143.85 pmol/ml, two hours 9.93-124.9 pmol/ml, three hours 5.06-25 pmol/ml. (Approximate normal range: normal 5-25; 1 hour is 5-10 times the amount of fasting insulin secretion and is the highest peak; 2 hours is between fasting-1 hour.)