During the progression of diabetes, poor glycemic control, or the combination of infection or stress (e.g., trauma, surgery, mood swings) can lead to an increase in the production of a substance in the body called ketone bodies. So where do ketone bodies come from and what do they mean? Where do ketone bodies come from? Whether type 1 diabetes or type 2 diabetes, when combined with infection and stress, the body needs glucose to provide energy, but when infection and stress, the body will have a serious lack of insulin, at this time, the blood sugar will be very high, but can not be used to provide energy, in order to ensure the normal physiological needs of the human body, the body has to break down fat to provide energy, then, in the breakdown of fat, a kind of metabolic waste is produced. In order to ensure the body’s physiological needs, the body must break down fat to provide energy, then, in the breakdown of fat, a metabolic waste is produced, which is ketone body. Does a positive ketone body necessarily mean diabetic ketosis? In fact, there are traces of ketone bodies in the serum of normal people, but they are not detected by the laboratory. If a normal person fasts for a long time, or after a long period of physical labor, the body will not have enough glucose to produce ketone bodies, called starvation ketone bodies, which can also be detected by the laboratory, but will disappear quickly after eating normally or replenishing energy. Also, ketone bodies can sometimes be detected in newborns and pregnant women. Only ketone bodies detected in the blood and urine of diabetic patients, and only after starvation ketone bodies have been excluded, can be called diabetic ketosis. Do urine ketone bodies and blood ketone bodies always appear at the same time? Many patients may find that blood ketone bodies and urine ketone bodies are not always present at the same time in clinical practice. This is because the main components of blood ketone bodies and urine ketone bodies are different in laboratory tests, and the time for blood ketone bodies and urine ketone bodies to turn negative during disease progression is different, so they may not appear and disappear at the same time. What if ketone bodies are detected? If ketone bodies are detected in the blood or urine of diabetic patients, they must be treated regularly and insulin must be applied regularly, with special attention to the fact that oral hypoglycemic drugs cannot be applied during ketosis, and it is best to go to a professional endocrinology department for ketone elimination treatment.