Numbness of the toes may be caused in diabetic patients with associated peripheral neuropathy. Peripheral neuropathy is a common complication of diabetes mellitus, and distal symmetric polyneuropathy is the most common type, so the lesions are usually symmetric, and the first abnormal sensation of limbs can be manifested as bilateral symmetric numbness of toes, and the later sensation can be lost, and sensory ataxia occurs. Diabetic patients with peripheral nervous system lesions, need to be under the guidance of a professional doctor to carry out regular drug therapy, active control of blood glucose, the application of methylcobalamin, lipoic acid, etc., can reduce the symptoms, but the symptoms will not completely disappear. In addition, local massage, acupuncture and other traditional Chinese medicine can also help to relieve the symptoms. If diabetic patients have numbness of the toes, it is recommended to consult a doctor in time to clarify the cause of the disease, and regular treatment under the guidance of the hospital.