It is more common to have a cough that keeps you awake at night, and if the cough is more severe, it can lead to sleeplessness, and there are more causes of coughing. If a serious respiratory infection occurs, the mucous membrane of the respiratory tract will have inflammatory exudates that will constantly stimulate the respiratory system, resulting in a severe cough. Using anti-inflammatory drugs to relieve inflammation can effectively relieve the phenomenon of a strong cough at night. For example, according to the type of infection, appropriate antibiotics and antiviral drugs can be chosen for anti-inflammatory treatment. Before going to bed, oral cough expectorants such as aminoglutethimide oral solution and pulmonary cough combination can be used. Another cause may be the occurrence of allergic cough or cough variant asthma, both of which are more serious and can lead to sleepless nights. In this case, nebulized inhalation of terbutaline sulfate and budesonide is recommended before going to bed, which can effectively relieve the symptoms of cough.