Acne, known in ancient times as pimples and acne, is a common chronic inflammatory skin disease of the follicular sebaceous glands, mostly on the face. Since the disease is common in young men and women, especially in patients with oily skin, it also has the name of acne, which is also known as acne in Cantonese. Clinical manifestations are dominated by blackheads, inflammatory papules and pustules, nodular cysts, and scarring and other damages, so when we treat the lesions, we have to Different treatment methods are used depending on the lesions. Oral medications Antibiotics are used to inhibit bacteria and reduce the production of free fatty acids, thus reducing the inflammatory response. Commonly used are memantine, azithromycin, and metronidazole. Endocrine inhibitors: Estrogens or estrogen substitutes can inhibit or counteract androgen levels, thereby reducing androgen stimulation of the sebaceous glands and indirectly reducing the occurrence of acne, such as momoflavone and daimon-35. Retinoids: Isotretinoin can inhibit sebaceous gland activity, reduce sebaceous gland secretion, reduce keratinization of the follicle opening and sebaceous island opening, in addition to having anti-inflammatory activity. Glucocorticoids can inhibit hyperadrenocorticism and can be used for coalescent acne or violaceous acne. Topical treatment For mild to moderate acne and inflammatory acne, we can choose, for example, to use adapalene gel or all-trans retinoic acid. For pustular and papular lesions, we can use topical antibiotics such as tetracycline or erythromycin, clindamycin, chloramphenicol, etc., but it is not easy to use them for too long to prevent drug resistance. Intense pulsed light and fruit acid peels are aimed at near-inflammatory acne.