Diffuse flushing refers to a group of symptoms characterized by flushing and edema of the skin in multiple areas of the body. There are many causes of generalized flushing, so it is important to detect them in time and treat them according to different causes. Diffuse flushing is commonly seen in erythrodermic disease, which is easier to diagnose. Erythroderma is a serious skin disease with systemic symptoms of widespread redness, swelling and flaking of the skin. Erythrodermic disease occurs before malignant tumors and is associated with various lymphomas, especially Hodgkin’s disease, but also with adenocarcinoma and lung cancer. Erythroderma should be diagnosed not only from the symptoms, but also differentiated from toxic epidermal necrolysis relaxation type drug rash and deciduous aspergillosis. 1. Mucosal symptoms: The symptoms are more obvious and may include ocular conjunctivitis, blepharitis, keratitis, corneal ulcers, oral erythema, ulcers, and pain, and the symptoms are aggravated when swallowing. The mucous membranes of the female genital, urethra, and anal areas are often eroded and have secretions. 2. Increased body temperature: Under normal circumstances, the body maintains a dynamic balance between heat production and heat dissipation processes. Erysipelas patients can cause different degrees of fever due to the absorption of toxins and malfunction of skin heat dissipation, and most patients have a body temperature of about 38℃ to 39℃. If high fever and toxic symptoms are evident, concomitant infection should be considered. 3.Lymph node enlargement: 2/3 of patients with erythrodermic disease have different degrees of lymph node enlargement, among which the inguinal and axillary lymph nodes are most involved, followed by the neck. 4. Endocrine changes: A few male patients may have feminization of the breasts, testicular atrophy, and reduction of spermatozoa. In women, it may lead to menstrual disorders, breast tissue hyperplasia, and abnormalities of sex hormones and their metabolites. 5. Hepatosplenomegaly: About 1/3 to 2/3 of patients have hepatosplenomegaly. Erythroderma due to drug allergy and lymphoma has a higher chance of hepatosplenomegaly. If there is significant hepatosplenomegaly, malignant lymphoma should be considered. 6. Skin appendages: Hair loss, ranging from sparse hair in mild cases to extensive shedding in severe cases. The more serious the disease is, the more obvious the hair loss is, after recovery, the hair can be regenerated. Finger (toe) nails can appear atrophy, cloudiness, depression, etc., especially psoriatic erythroderma caused by the most obvious nail changes.