The treatment of hepatitis B, major tri-positive should be determined on a case-by-case basis. If the liver function is normal and the patient is in a state of virus carriage, there is no need to deal with it and regular observation can be done. If the aminotransferase is elevated within twice the normal value, you can first carry out liver-protective and enzyme-lowering treatment by taking common liver-protective drugs, and if the effect is not good, you can consider antiviral treatment. If the transaminases are elevated more than 4-5 times the normal value, and the viral replication will be obvious (high quantitative level of HBVDNA), the use of interferon or nucleoside antiviral therapy can be considered when the economic condition permits.