The symptoms of soreness in the calf may be caused by muscle strain, atherosclerosis occlusive disease, varicose veins, sciatic nerve compression and other factors, and the specific types of drugs chosen are not the same, the relevant causes and medications are as follows: 1, muscle strain: muscle damage caused by prolonged overexertion, cold, causing soreness in the calf, you can apply non-steroidal anti-inflammatory analgesics to relieve muscle soreness, such as diclofenac sodium, Loxoprofen sodium, Nimesulide, etc.; 2, atherosclerosis occlusive disease: atherosclerosis occlusion distal blood supply is insufficient to cause ischemia in the lower leg, causing pain. On the one hand, anti-atherosclerosis and anti-platelet drugs, such as aspirin and clopidogrel, can be taken orally to prevent thrombosis. On the other hand, cilostazol tablets can dilate blood vessels to prevent clotting; 3, varicose veins: poor venous blood circulation leads to pain caused by varicose veins, you can give vasodilator drugs to improve microcirculation, such as beriberi sodium tablets, and at the same time, you can take oral cefadroxil tablets for anti-inflammatory treatment; 4, sciatic nerve compression: lumbar disc herniation compresses the sciatic nerve causing calf pain, you can apply anti-inflammatory analgesics, such as nimesulide dispersible tablets, celecoxib capsules to relieve pain, cloxazone, tizanidine can relax the muscle and prevent spasm. In addition, patients with sore calf muscles can also apply physiotherapy, such as hot compresses and baking electricity, to activate blood circulation and relieve pain. If there is no relief of symptoms and recurrent attacks, it is important to seek medical attention for symptomatic treatment.