Cervical spondylosis and depression are very different, with painless causative factors and different clinical symptoms, and their treatment options and prognosis are significantly different. Cervical spondylosis is a nerve injury caused by herniated discs, osteophytes and hypertrophy and calcification of the ligaments in the cervical spinal canal in the neck. The causes of depression are very diverse and are related to a variety of biological, psychological, and social environmental reasons. The main symptoms caused by cervical spondylosis are abnormal sensation of the limbs and abnormal reflexes, which can lead to tetraplegia in severe cases. Patients with depression mainly present with depressed mood, slowed thinking, reduced volitional activity, and cognitive impairment. Cervical spondylosis has both surgical and conservative treatments, while depression is mainly treated with psychological guidance and medication.