Human papillomavirus (HPV) is a virus that can be transmitted through sexual intercourse. Infection with this virus is usually asymptomatic, but persistent infection can cause a variety of diseases and even induce malignant tumors such as cervical cancer. To date, more than a hundred types of HPV have been identified, and different types of HPV cause different diseases, among which HPV type 16 is a high-risk type that causes cancer. Therefore, according to the current expert consensus on the problems related to HPV-infected diseases, patients are recommended to prevent them through the following matters: 1. Visit the hospital gynecology department for liquid-based cytology (TCT) examination, p16INK4a and Ki-67 double-staining method (detection of viral proteins), high-risk HPV oncogenes E6/E7 mRNA, multiple methylation and DNA ploidy detection. If one is positive, referral for colposcopy is recommended. Depending on the colposcopy, it is determined whether the patient will undergo a cervical pathology biopsy. Some guidelines also suggest that colposcopy may be performed directly if HPV-16 is positive, but the specifics should be decided by the patient in consultation with the physician after the visit; 2. If all tests are abnormal, a high-risk PCR-HPV-DNA typing retest is recommended after 1 year, and if the test is negative, it indicates that the HPV virus has been cleared. At the same time, it is recommended that the partner should also do PCR-HPV-DNA typing test. If the male partner is confirmed to have HPV infection, he should take precautions to avoid HPV infection again as much as possible; if the test result is positive, he needs to continue to follow up with the review on time. It is important to note that even for high-risk types, there is a possibility of conversion to negative. Because the body’s own immune mechanism can clear HPV, most genital tract HPV infections are transient, and about 90% of HPV infections can subside within 2 years. The regression time is mainly determined by the type of HPV, with high-risk HPV taking 8-24 months, and only a very small number of HPV infected patients can develop cancer. Therefore, even if HPV high-risk type is found to be positive, but other tests are negative, patients do not need to worry too much, as long as they are reviewed regularly.