The known indications of ozone autotherapy cover almost all kinds of diseases from cardiovascular, cerebrovascular and peripheral vascular diseases, to renal diseases, digestive system diseases, hematological diseases, endocrine diseases, geriatric diseases, infectious diseases,, venereal diseases, dermatological diseases, burns, tumors, surgery, pain, orthopedics and so on. Moreover, it is very effective in treating cardiovascular and cerebrovascular diseases and chronic pain. It avoids the adverse reactions brought about by drugs, and the long-term efficacy is much higher than the effect of drug treatment. Ozone autotransfusion is a method in which the patient’s own venous blood is pumped out in a certain amount, treated with ozone gas, and then returned to the body to treat certain diseases. It includes major autologous blood and minor autologous blood therapy. Large autologous blood is usually drawn 100-200ml of blood/session, treated with equal amount of ozone and then infused back into the vein; small autologous blood is usually drawn only 5ml/session, treated with ozone and then injected intramuscularly, usually into the gluteus maximus muscle. Ozone is a strong oxidizing agent, and ozone autologous blood therapy is a kind of chemotherapy. Through the treatment, it can activate a variety of enzyme systems in the patient’s body, improve the body’s metabolism, adjust the immune function, and also has the effect of killing pathogenic microorganisms. The main physiological effects of ozone authemotherapy are: First, it has a very strong oxidative capacity. Ozone injected into the intervertebral disc can rapidly oxidize the proteoglycans in the nucleus pulposus, causing the destruction of the cell membrane and intracellular structure of the nucleus pulposus, resulting in cell degeneration and necrosis, and the decrease or loss of the function of cell synthesis and secretion of proteoglycans, so that the osmotic pressure of the nucleus pulposus is reduced, resulting in water loss and reduction of the volume of the nucleus pulposus. Second, anti-inflammatory effect. Ozone can stimulate the overexpression of oxidative enzymes, neutralize the overproduction of reactive oxidative products in the inflammatory response, dilate blood vessels, improve reflux, and reduce edema around nerve roots. Third, analgesic effect. Ozone injection can act directly on nerve endings and stimulate the release of enkephalins and other substances from inhibitory interneurons, thus providing analgesia. What diseases can be treated by ozone autologous blood transfusion therapy? 1.Ischemic and hypoxic diseases: cerebral thrombosis, cerebral infarction, angina pectoris, arrhythmia, bradycardia, diabetic gangrene, etc. 2, immune diseases: rheumatoid arthritis, rheumatoid arthritis, ankylosing spondylitis, psoriasis, lupus erythematosus, etc. 3, inflammatory infectious diseases: necrotic ulcers, animal bites, hard-to-heal wounds, burns, etc. 4, atherosclerosis, vasculitis, etc. 5.Metabolic diseases: gout, hyperlipidemia. What are the technical advantages of ozone autologous blood transfusion therapy? 1.It can cause a significant increase of oxygen partial pressure in plasma. 2.The same situation leads to a significant increase of redox point level. 3.It leads to a significant improvement of oxygen osmolarity in arterial blood and, at the same time, improves oxygen distribution in tissues. 4.Increased partial pressure of oxygen in blood red blood cells and the corresponding increase in redox potential are directly related. Ozone autologous blood transfusion therapy has been used for many years as an alternative treatment. Ozone is highly oxidizing, but human blood can neutralize appropriate concentrations of this oxidizing property, and tens of thousands of patients have received ozone autologous blood therapy without acute or chronic side effects, which is where the advantages of ozone autologous blood transfusion therapy lie.