With standard treatment, H. pylori can be eradicated. However, there is a large individual variation in treatment outcome, which is influenced by bacterial resistance, feasibility of the treatment regimen and patient compliance. The success of treatment regimens is greatly reduced when patients do not take the full amount of medication on time and have recurrent infections; when bacteria develop a high level of resistance to drugs; and when some patients metabolize proton pump inhibitors more rapidly and the drugs do not reach effective concentrations. All may be the reason why complete eradication of H. pylori cannot be achieved. For first-time patients, it is recommended that quadruple therapy, which is a quadruple therapy of proton pump inhibitor + two antibiotics + bismuth, is preferred. The original triple therapy used, although less expensive, will lead to drug resistance in case of treatment failure, causing difficulties for future treatment, and is not recommended. Treatment usually lasts 7 to 14 days, and if the discomfort caused by the drug is tolerated, it is recommended that it should preferably last 14 days. The breath test is repeated after 1 month of discontinuation of the drug. Repeated use of the drug without a clear indication of the effectiveness of the infection treatment is not recommended, as there is no guarantee of efficacy with the drug and it can lead to an increase in adverse reactions. If a single treatment fails to eradicate the infection, it is recommended to treat it again after an interval of six months. The morphology and sensitivity of H. pylori to drugs will change within a short period of time after the end of medication, making it difficult to eradicate the bacteria with short-term medication and increasing adverse reactions. Clinically, because of the complexity of H. pylori treatment with drugs, it is recommended to go to the hospital to be interviewed by a professional doctor after the use of drugs.