Every year, there are about 200,000 new children with precardiac disease in China, which means that every 10 minutes, 3 newborns come into the world with a defective heart, bringing great misfortune and a heavy burden to families and society. Pediatric precardiac disease is the highest mortality rate of the disease, especially in newborns with precardiac disease, if not treated in a timely manner, the mortality rate is extremely high. The following seven factors are important triggers for fetal heart development malformations. Viral infections Women in the first three months of pregnancy, especially from 3 weeks to 8 weeks of pregnancy, such as viral infections, the fetus is prone to cardiovascular malformations. The rubella virus is the main culprit of fetal precocious heart disease. In addition, influenza, mumps, coxsackie virus, herpes virus, etc. are also often the “perpetrators” of pediatric precocious heart disease. Bad habits Pregnant women who are addicted to “swallowing fog” or husbands who smoke or wives who “passively smoke” can lead to fetal malformations or prediabetes. The incidence of precocious heart disease in infants is two times higher in babies born to mothers who smoke than to mothers who do not smoke. Conception after drinking” can cause chromosomal abnormalities in the fetus, and most babies born with alcoholism have cardiovascular abnormalities. Family history It is not uncommon for siblings to suffer from precocious heart disease at the same time, or for parents and children to suffer from precocious heart disease at the same time, and the nature of the disease is very similar. If the first child born to a mother with precocious heart disease, the likelihood of the second child having the disease is about 2%; if two consecutive children are born with precocious heart disease, the number of new children with precocious heart disease may increase to 10%. If the mother suffers from precordial disease, the risk of the second generation suffering from precordial disease is 10%. Inbreeding is a high-risk factor for fetal malformation and precocious heart disease. Pregnant women with untreated and uncontrolled diabetes mellitus have a 2% risk of fetal congenital heart disease, and the risk decreases if the disease is controlled and stable in early pregnancy. Drug-induced Exposure to teratogenic drugs such as lithium, phenytoin sodium or steroids in early pregnancy can lead to a 2% risk of fetal congenital heart disease. At present, there are five methods for prenatal diagnosis of precocious heart disease: 1. Pre-marital examination can detect patients with precocious heart disease and their relatives in time to know whether a history of the disease exists. 2, timely detection of pregnancy abnormalities and causes of miscarriage through fertility guidance. 3.Regular pregnancy checkups to detect abnormal pregnancies in a timely manner, it is worthwhile to propose a high-risk group for precardiac disease. Fetal echocardiography should be performed as soon as pregnancy occurs, which can be done at 16-20 weeks of gestation, when abnormal cardiac malformations such as permanent arterial trunk, transposition of the great arteries, ventricular septal defect, tetralogy of Fallot, etc. can be detected. Once detected, abortion and induction of labor should be performed as early as possible, which is of great importance for the implementation of eugenics. Of course, the specific operation depends on the actual situation of each family. 4.Improve the level of obstetrics technology to reduce the occurrence of preterm birth, neonatal asphyxia, etc., and also reduce the occurrence of precocious heart disease. 5.Fetal microscopy, direct observation of fetal morphology, taking blood samples and amniotic fluid for chromosome examination. Special protein determination, metabolites, enzyme activity check, etc.