Objective To retrospectively summarize 136 chronic coronary occlusion (CTO) cases of coronary intervention (PCI) in order to investigate the safety, feasibility, and influencing factors of the procedure. METHODS 136 CTO cases were given conventional medication before the procedure and underwent coronary intervention via radial or femoral artery route to summarize the target lesion guidewire passage rate, immediate success rate of PCI treatment, factors influencing the success rate of the procedure, the procedure time and contrast dosage, the incidence of serious complications during the procedure and hospitalization, postoperative angina episodes, and recovery of cardiac function. Results There were 1.2 CTO lesions per capita and 1.3 stents per capita placed in 136 patients. The guidewire passage rate at the occlusion was 89%, the immediate PCI success rate was 80.9%, and the procedure time ranged from 1 to 5 hours, with an average of 2.3 hours. Postoperative angina episodes were significantly reduced, cardiac function was significantly improved, and there were no deaths during the operation or hospitalization, and no serious complications that could not be saved. Conclusion Successful PCI treatment in CTO cases improves patients’ quality of life without serious complications, and the success rate of the operation is significantly improved with the maturity of the operator’s technique and the improvement of equipment. The success rate of the procedure is closely related to the experience of the operator, the general condition of the patient, the duration of coronary occlusion and the location and characteristics of the occluded lesion, the reasonable application of interventional devices and surgical techniques, and there is no significant correlation with the route of intervention.