While IVF satisfies the couple’s desire to raise a child, does it occur to you that there is also the possibility of hereditary diseases and facing the disaster of genetic diseases? When I saw yesterday the third IVF baby born with the onset of the disease, I had to tell you quickly to draw attention to it. In October last year, we found the first case of pseudohypertrophic myotonic dystrophy caused by IVF, in which the child had difficulty walking at the age of 3 and, if left untreated, usually did not live to adulthood before dying, and since the mother did not have the relevant genetic mutation, there was only one possibility for this sex-linked disease to have a problem with the egg donor or a genetic mutation caused by external factors; since then, at the beginning of this year, another case of IVF was found The child’s genetic mutation is clear, the mother does not have the mutated gene, and the sperm taken from an anonymous supplier, so it is doubtful whether he is healthy; yesterday another IVF baby was found to have congenital muscular disease, and again the child’s causative gene did not come from the mother, but from the sperm supplier or other foreign factors caused the onset of the child. The appearance of three IVF cases in a short period of time for a rare genetic disease has to alert us to the possibility that IVF leads to a higher incidence of genetic disease than in the natural state. Not only does IVF not bring happiness to a family, it is a huge disaster for the family in the current situation of inadequate social security. A comprehensive analysis of its causes and the measures that need to be taken are broadly as follows: 1. The existence of genetic diseases in the egg or sperm supplier. Since all of the above genetic diseases have early onset and the supplier has obvious symptoms, the IVF implementation unit should identify them or conduct screening of the donor for the disease-causing gene. If someone intentionally gives sperm or eggs with disease-causing genes to the recipient, it should be a criminal act. 2. There are extrinsic factors that cause genetic mutations during the IVF operation, which occur during culture and implantation in the mother’s uterus. IVF requires pre-implantation screening for disease-causing genes to determine if the embryos are healthy. IVF is a highly technical endeavor and the above recommendations should be adopted immediately, otherwise more catastrophic events will gradually become apparent and it is time for administrators to take action to stop the type of situation from occurring.