Bevacizumab indications usage and side effects

Indications: In combination with fluorouracil/folic acid or in combination with fluorouracil/folic acid/irinotecan for the first-line treatment of metastatic colorectal cancer and in combination with certain chemotherapy regimens for the treatment of advanced non-small cell lung cancer. Precautions: 1. Should be permanently discontinued in case of gastrointestinal perforation. 2. There is a potential risk of affecting wound healing. 3.Blood pressure should be monitored during treatment. Treatment should be suspended in case of severe hypertension requiring treatment, and should be permanently discontinued in case of uncontrollable hypertension, hypertensive crisis or hypertensive encephalopathy. 4.Urine protein should be monitored before and during treatment, and should be discontinued in case of grade 4 proteinuria (nephrotic syndrome). 5.Serious arterial thrombotic events should be permanently discontinued. 6.Not for patients with existing CNS metastases. 7.Patients who have had bleeding after the use of this product should be permanently discontinued. 8.The risk of congestive heart failure is increased and should be taken into account when using the drug. 9, Pregnant women should be used with caution, and lactating women should stop breastfeeding. Contraindications: Hypersensitivity to the active substance or excipient components, hypersensitivity to Chinese hamster ovary cell products or other recombinant human or human-derived antibodies. Adverse Reactions: Gastrointestinal perforation, hemorrhage, arterial thrombosis, debilitation, diarrhea, nausea, pain, hypertension, proteinuria, slowed wound healing, reversible posterior leukoencephalopathy syndrome, tumor-related hemorrhage, mucocutaneous hemorrhage, thromboembolism, congestive heart failure/cardiomyopathy, neutropenia, leukopenia. Dosage and Administration: Intravenous drip: 5mg/kg once, administered every 14 days. Dilute with sodium chloride injection. The first drip should be given after chemotherapy and should last longer than 90 minutes. Subsequent doses can be given before or after chemotherapy, and the drip time can be shortened if well tolerated