Lung adenocarcinoma is a pathological type of bronchopulmonary cancer, and differentiation refers to the degree of differentiation of the tumor, that is, the degree of resemblance to normal tissue. Hypodifferentiation refers to a low degree of resemblance to normal tissue and generally predicts a higher degree of malignancy of the tumor.
There are six pathological types of bronchial lung cancer: squamous cell carcinoma, adenocarcinoma, adenosquamous carcinoma, small cell carcinoma, large cell carcinoma, and sarcomatoid carcinoma. Adenocarcinoma is one of the pathological types of bronchopulmonary carcinoma. In contrast, hypofractionation describes the degree of differentiation of the tumor. The degree of differentiation of a tumor refers to how similar the function and morphology of tumor cells are to normal cells. The more similar the tumor is to normal tissue, it is described as well differentiated or highly differentiated, if the tumor is less similar to normal tissue, it is described as poorly differentiated or hypo-differentiated. Generally, the degree of differentiation is described as low, intermediate or high differentiation. Hypofractionated adenocarcinoma of the lung means that the pathological type of bronchial lung cancer is adenocarcinoma with a low degree of resemblance to normal tissue. Cells that are generally hypodifferentiated are more malignant than those that are highly differentiated, suggesting that patients have a poorer prognosis.