1. Most patients with early stage lung cancer have no obvious associated positive signs.
2. Patients present with unexplained and persistent extrapulmonary signs, such as pestle and mortar fingers (toes), non-ambulatory joint pain, gynecomastia, dark skin or dermatomyositis, ataxia and phlebitis.
(toe), non-volatile joint pain, male breast development, dark skin or dermatomyositis, ataxia and phlebitis.
Patients with high clinical suspicion of lung cancer and physical examination findings such as vocal cord paralysis, superior vena cava obstruction syndrome, Horner syndrome, and Pancoast syndrome suggest the possibility of local invasion and metastasis.
4. In patients with high clinical suspicion of lung cancer, liver enlargement with nodules, subcutaneous nodules, and enlarged lymph nodes in the supraclavicular fossa on physical examination suggest the possibility of distant metastasis.