Can cirrhosis be inherited?

  For whether cirrhosis is hereditary, I believe that many patients are also concerned about the problem, for this problem, we first need to figure out the different causes of cirrhosis, for different causes to specific problems, specific analysis.  The most common cause of cirrhosis is viral hepatitis, the most common of which are viral hepatitis B and C. It should be noted that hepatitis B and C are infectious diseases that are transmitted through blood, mother-to-child vertical transmission and sexual intercourse, but they are not hereditary.  Alcoholism is the second major cause of cirrhosis. Long-term alcohol consumption leads to necrosis and degeneration of liver cells, which in turn leads to liver fibrosis, and in the long term, irreversible liver cell damage leads to cirrhosis, commonly known as alcoholic cirrhosis.  Schistosomiasis can also cause schistosomiasis cirrhosis, as schistosomes infect the human body, parasitic in the portal system, the eggs produced by them will be deposited in the branches of the portal vein, causing liver fibrosis, and eventually the formation of cirrhosis. Nowadays, with the active development and attention to schistosomiasis prevention and treatment, the prevalence rate is significantly lower than before. According to the cause of the disease, we can know that schistosomiasis cirrhosis is also not hereditary.  There is another type of cirrhosis caused by obstruction of hepatic venous return. This type of cirrhosis is caused by obstruction of hepatic venous return due to lesions above the liver, which in turn causes damage to liver cells, degeneration, necrosis, liver fibrosis, and eventually cirrhosis. This type of cirrhosis is common in diseases such as constrictive pericarditis and right heart insufficiency (i.e., right heart failure). This type of cirrhosis is also not hereditary.  In primary biliary cirrhosis, biliary stasis causes high levels of bilirubin and bile acids to damage liver cells, eventually leading to cirrhosis. This type of cirrhosis is often related to autoimmunity, and this type of cirrhosis is somewhat hereditary.  Cirrhosis caused by inherited metabolic disorders, mostly seen in hepatomegaly caused by copper deposition, hemochromatosis caused by iron deposition, and hereditary fructose intolerance. This type of cirrhosis is also hereditary in nature.  In addition, there are drugs and toxic substances that cause cirrhosis, for example, the drugs such as dogbane contain wild lily of the valley, which causes occlusive disease of the small veins of the liver, leading to cirrhosis, which is not hereditary.  Finally, there is a very small number of cirrhosis due to unknown causes, which is collectively called cryptogenic cirrhosis, and there is no clear basis to confirm that this type of cirrhosis is hereditary.