Gastroesophageal reflux disease is a relatively common disease that many people have suffered from and know well. Its typical symptoms are acid reflux and heartburn, while its atypical symptoms are varied and involve multiple specialties and systems, and patients often travel to and from various hospital departments. As the saying goes, headaches are treated as headaches and feet are treated as footaches, and doctors are busy with their own, looking at digestion in gastroenterology, breathing in respiratory medicine, ear, nose and throat in ENT, and heart in cardiology, diagnosing a whole lot of things, such as allergic asthma, coronary heart disease, chronic pharyngitis, allergic rhinitis and so on, and prescribing a whole lot of drugs, with little effect. There is a development trend in modern medicine, that is, the more subspecialties, such a division of labor, has its advantages – doctors are easy to be proficient in the diagnosis and treatment of a particular disease, but also its disadvantages, it is the whole person artificially divided, who do not know that people can not only suffer from a disease, a disease may also have a variety of manifestations. In this case, if the doctor lacks a holistic view and has little lay knowledge, the situation described above may easily occur, making the diagnosis of GERD, which is very simple, into a variety of diseases. Below I list the symptoms of GERD involving each system for your reference. 1, digestive system: acid reflux, heartburn, bloating, belching, regurgitation, diaphragm, epigastric pain, dysphagia, mouth ulcers, diarrhea or constipation, some patients complain of foreign body or pressure in the esophagus or subxiphoid process. 2.Respiratory system: cough, coughing sputum, wheezing, laryngeal tinnitus, hoarseness, tightness in the throat, chest tightness, breath-holding, shortness of breath, sneezing, runny nose, nasal congestion, post-nasal drip, dry throat, itchy throat, foreign body sensation in the throat. 3.Circulatory system: chest pain, palpitation, arrhythmia. 4.Motor system: back pain, numbness of skin on head or limbs, limb paralysis, tooth decay. Seeing this, one must be overwhelmed with surprise that a small GERD can cause so many problems that are commonplace but never properly looked at. That’s why it’s so important to take GERD seriously. Let’s start with the people around us and spread the knowledge of GERD widely so that more patients can be freed from the misdiagnosis and mismanagement as soon as possible.