Typical manifestations of patients with rheumatoid arthritis are as follows: 1. Morning stiffness: usually morning stiffness lasts for more than 1h before it becomes clinically significant, and can be used as one of the indicators of whether rheumatoid arthritis is in an active phase. However, because of the strong subjective judgment, the accuracy of diagnosis is not high; 2. Joint pain: common in the wrist, proximal metacarpophalangeal joint, elbow, knee, hip, etc.. The pain is symmetrical and sometimes mild; 3. Joint swelling and pain: the affected joints are obviously swollen and also symmetrical; 4. Functional changes of joints: stiffness of joints, inability to complete extension and flexion movements, etc., all of which indicate impaired joint function; 5. The above symptoms are the more characteristic manifestations of rheumatoid arthritis; 6, extra-articular manifestations: such as rheumatoid nodules appear under the skin, can involve the lungs, pulmonary interstitial fibrosis, causing pulmonary hypertension. It can also cause nerve compression and neurological damage.