If a thrombus develops in a vital vein after PICC placement, it is not acceptable to administer fluids. Continuing to administer fluids may dislodge the thrombus, resulting in myocardial infarction or pulmonary embolism. PICC cannulation is to use catheter to puncture the vein from the peripheral arm, and the catheter directly reaches the large vein close to the heart, usually in the vital vein, cephalic vein, and elbow median vein of any one of them. In the case of venous thrombosis, an ultrasound or angiogram is necessary to clarify the condition and identify the cause of the condition. Massage, pneumatic compression therapy, intravenous drug injection and so on are forbidden on the side of venous thrombosis to reduce the stimulation to the thrombus, you can elevate the affected limb, and ask the vascular surgery department to consult the doctor for surgical treatment or oral anticoagulant treatment (such as rivaroxaban, which should be used according to the doctor’s instruction). Note: PICC tube after the emergence of thrombosis in the veins of your first extraction and then treatment or treatment after extraction, need to comply with medical advice, do not blindly operate.