Body cavity thermal perfusion therapy is a kind of treatment for malignant body cavity effusion, if chemotherapeutic drugs are added to the perfusion solution, it is body cavity thermal perfusion chemotherapy. Principle: 1. Malignant tumor cells are more sensitive to temperature above 42℃, and tumor cells are easily inactivated; 2. Body cavity thermal perfusion chemotherapy has obvious pharmacokinetic advantages, with higher bioavailability and less systemic side effects; 3. Thermal effect can enhance the permeability of anti-cancer drugs and deepen the penetration depth of drugs from 2mm–3mm to 5mm; 4. During abdominal cavity thermal perfusion chemotherapy, drugs are absorbed into blood through portal vein The absorption into blood can increase the concentration of drugs in portal vein, which can help to inhibit or destroy the tiny metastases in the liver. Application scope: 1, fluid accumulation in body cavity (including pericardial cavity, thoracic cavity and abdominal cavity) caused by malignant tumor; 2, early pleural mesothelioma, which can obtain very satisfactory effect; 3, pleural, peritoneal or abdominal metastasis; 4, free cancer cells in body cavity; 5, gastrointestinal tumor infiltrating plasma membrane or extra-plasma membrane. Common side effects: nausea, vomiting, abdominal distension, etc. This method also has better effect on intractable and refractory malignant body cavity effusion, which can reduce patients’ pain and prolong their survival period.