Artificial insemination (AI) is an assisted reproductive technology that involves artificially injecting treated semen into the female partner’s reproductive tract to cause pregnancy. Indications for artificial insemination with husband sperm (AIH): low, weak or abnormal spermatozoa and sexual dysfunction in the male partner; cervical factors in the female partner; immune infertility; and infertility of unknown origin. (Prerequisite: the female partner’s fallopian tubes are bilaterally or unilaterally patent). If the indications for AIH are met, the routine treatment time from the beginning of preparation to the end is about 2-3 months; the treatment cost is routinely about $6-8,000. In vitro fertilization-embryo transfer (IVF-ET), commonly known as the first generation of IVF, refers to the process of using ovarian stimulating drugs to make the ovaries of infertile women have multiple follicles mature at the same time, obtaining mature eggs through vaginal puncture at the right time, fertilizing the retrieved eggs with the sperm of her husband in the laboratory, culturing them into embryos and then implanting them into the woman’s uterus. The embryo is then implanted in the woman’s uterus and continues to reproduce. (The photo above shows the world’s first IVF baby in July 1978 – Louise Brown and her two children) Indications for IVF-ET: tubal factors (blockage, hydrocele, absence or adhesion of the fallopian tubes); ovulation disorders; endometriosis; low or weak sperm count in the male partner; unexplained infertility. If you meet the indications for IVF-ET, the routine treatment time from the beginning of preparation to the end is about 3 months; the cost of treatment is routinely about 30,000 RMB. Intracytoplasmic sperm injection (ICSI), commonly known as the second generation of IVF, is a technique in which a single sperm is injected directly into the egg plasma under a microscope to fertilize the egg, which is then cultured into an embryo and transferred into the uterine cavity of the female partner to achieve pregnancy. ICSI indications: severe oligospermia, weakness and malformation of the male partner, abnormal sperm acrosome function, irreversible obstructive azoospermia (diagnostic testicular aspiration can find motile sperm), spermatogenic dysfunction (excluding genetic defects); immune infertility; in vitro fertilization rate <30%; preimplantation embryo genetic examination is required. If the indications for ICSI are met, the conventional treatment time from the beginning of preparation to the end takes about 3 months; the cost of treatment is about 40,000 RMB.