Patients with essential thrombocythemia are advised to quit smoking, otherwise it is not conducive to the control of the disease. Although smoking does not directly affect platelet production, cigarettes contain a large amount of tar and nicotine and other toxic substances, these toxic substances into the body, easy to affect the normal function of the hematopoietic system. Primary thrombocythemia will result in excessive platelet production, and smoking will lead to an increased chance of thrombosis, worsening the degree of damage to the condition. Primary thrombocythemia is a chronic myeloproliferative disorder that predisposes to bleeding, thrombosis, and enlargement of the spleen. Toxic substances ingested during smoking can also cause damage to the spleen. Patients with essential thrombocythemia need to receive regular treatment under the guidance of a physician and quit smoking and drinking.