In the long run, the entire population should receive a 3rd booster dose to strengthen their ability to fight the new coronavirus, conditions permitting. However, in contrast, the current focus is on getting the unvaccinated cohort vaccinated first to reduce the risk of virus transmission and to construct a healthy immune barrier, and the general population is not required to receive booster shots for the time being. However, staff exposed to imported high-risk populations, such as customs, border control, aviation, quarantine points, and staff of designated medical institutions; people with relatively low immune function, and people over 60 years old; and people with work, study, or exchange needs to travel to high-risk areas or countries with overseas outbreaks are recommended to receive a booster vaccination six months after vaccination. Studies have shown that 6 months after vaccination with the new crown vaccine, antibodies show varying degrees of decline, a pattern that is common with conventional vaccines. A booster vaccination after 6 months can effectively boost the number of antibodies in the body, and even though the regularity of antibodies decreases after another 6 months after the booster vaccination, it is higher than the peak of antibodies from 2 doses of vaccination. Therefore, from the point of view of immunogenicity, the booster shot can effectively boost the protective effect of the new crown vaccine.