At least 3 sputum specimens with negative smear microscopy for Bacillus acidophilus; ② at least 1 sputum specimen with negative culture for Mycobacterium; ③ negative bronchoscopy or bronchoalveolar lavage smear (Bacillus acidophilus) and culture (Mycobacterium); ④ histopathological examination of bronchus, lung and pleura confirmed tuberculosis-like changes; ⑤ chest imaging suggested suspicious active tuberculosis lesions (5) Chest imaging indicates suspicion of active tuberculosis lesions; (6) No significant resorption of lung lesions after 2-3 weeks of anti-inflammatory treatment, and repeated bacteriological tests (Mycobacterium antacidum and Mycobacterium) are still negative; (7) Other non-tuberculous lung diseases can be clinically excluded; (8) Effective anti-tuberculosis treatment. (2) Secondary indicators ① Strongly positive skin test for tuberculin (PPD 5TU); ② Positive serum anti-tuberculosis antibody or antigen; ③ Positive sputum Mycobacterium tuberculosis PCR or other new techniques related to mycobacteria; ④ Other histopathological examination outside the lung confirmed tuberculosis-like changes. Note: If the diagnosis of bacillus-negative tuberculosis cannot be made by relevant tests, the patient must have at least ①, ②, ⑤ (at least the results of chest X-ray), ⑥ and ⑦ of the main indicators, combined with the results of the secondary indicators that can be carried out for a comprehensive analysis, in order to make a diagnosis, or to confirm the diagnosis after effective diagnostic anti-tuberculosis treatment; if the conditions or reasons for not being able to carry out tuberculosis The diagnosis of smear-negative tuberculosis can only be made in primary care units that do not have the conditions or are unable to carry out culture of Mycobacterium tuberculosis for any reason; since the culture of Mycobacterium tuberculosis will take time, the diagnosis of smear-negative tuberculosis can be made by the admitting physician on the basis of other available evidence. Cases requiring diagnostic anti-tuberculosis treatment should be discussed and decided by at least three levels of physicians; individual difficult cases should apply for higher-level consultation in a timely manner, as appropriate.