There are many causes of premature ovarian failure, which are caused by a combination of causes, but in most cases the causes are not clear, and it is believed that they may be related to the following factors; 1. The first menstruation is early, the age of menopause is early, and premature ovarian failure amenorrhea occurs. 2, immune factors: patients with premature ovarian failure are often combined with autoimmune diseases of other endocrine glands or systems. For example: autoimmune thyroiditis, systemic lupus erythematosus, myasthenia gravis, hypoparathyroidism, rheumatoid arthritis, diabetes, etc. Some patients with premature ovarian failure may even have a combination of two or more autoimmune diseases. Among all the autoimmune diseases that accompany premature ovarian failure, thyroid disease is again the most common cause. These autoimmune diseases may present with premature ovarian failure before and after the onset of the disease. The cause of autoimmune diseases is still unknown, and there is no good way to prevent the occurrence of autoimmune diseases and premature ovarian failure. However, women should maintain a healthy lifestyle, is the best ovarian maintenance, found premature ovarian failure must be timely treatment.