Overview It is a type of interphalangeal neuroma that can cause chronic irritation and inflammation. Inferior and lateral pressure can lead to continuous compression of the toe nerve, with the toe nerve between the 3rd and 4th toes being the most susceptible. Predisposing factors for Morton’s neuroma include: occupations involving prolonged standing and constant stretching of the metatarsophalangeal joint; hammertoes; bunions and high heels. On examination, intermetatarsal head pressure pain is the most obvious; metatarsophalangeal joint compression sign is positive; there is no pain with passive movement of the joint; in severe cases, there is loss of sensation between the 2 adjacent toes. Diagnosis Local nerve block may be clear. Treatment Wide shoes; soft insoles; interdigital toe dominators; avoidance of unnecessary weight-bearing movements; reduced stride length during walking; local sealing are recommended. Surgery may be considered if symptoms persist for more than 3 months.