The patient, female, Jiangsu, 60 years old, was diagnosed locally due to a 3-month headache, and an egg-sized tumor was found located in the nasal cavity, orbital apex and skull base region. The tumor was superiorly and laterally adjacent to the optic nerve; laterally against the medial aspect of the middle cranial fossa, near the location of the round hole in the skull base, and in close relationship with the maxillary nerve of the trigeminal nerve; and superiorly against the cavernous sinus, with the internal carotid artery visible above the tumor against the tumor. As shown in Figure 1. The patient was told at the local consultation that the surgery was extremely risky and might cause irreversible damage to the nerves and blood vessels, and the surgery was life-threatening, and it was recommended to seek medical treatment in Shanghai. I received a diagnosis of neurogenic tumor at the base of the middle cranial fossa and considered a high probability of neurosynovial tumor. On the 4th day after admission, a skull base tumor resection through the natural nostril was performed, and the tumor was completely removed surgically. The MRI confirmed complete resection of the tumor with no residual after the postoperative review in three months. The patient’s general condition was excellent, and the headache completely disappeared. As shown in Figure 2.