Intermetatarsal neuroma is also called “Morton’s neuroma”. However, intermetatarsal neuromas are not true tumors, but rather tumor-like pathological changes after chronic mechanical stimulation of the common phalangeal nerve by long-term compression, mainly due to the proliferation of fibrous tissues in and around the nerve, increased fibroblasts and collagen fibers, and a tumor-like appearance. It may be related to gender, footwear and walking habits, chronic injury and nerve degeneration. The plantar interphalangeal nerve consists of branches of the internal and external plantar nerves, and can occur in any interphalangeal nerve, commonly between the second and third toes. Unilateral neuromas are more common than bilateral neuromas, and are more common in women than in men. Symptoms and signs Patients most often present with pain on the metatarsal side of the forefoot or toes, the pain is mostly burning, walking, wearing narrow shoes, high-heeled shoes can aggravate the symptoms, while rest, removing shoes or massaging the localization can relieve the symptoms. Some patients feel that there is a swelling on the metatarsal side of the toe webbing or numbness of the toes. Squeezing the foot from the inside and outside to the center of the foot, if there is localized pain, can help to diagnose. Sometimes a small swelling on the metatarsal side of the foot can be seen, and squeezing the swelling in the toe web space can cause pain. Toe sensation is usually normal, and a few patients may have hypesthesia. radiographs are of little diagnostic help, and ultrasonography is of some significance in the diagnosis of interphalangeal neuroma. The role of magnetic resonance imaging (MRI) in the diagnosis of interphalangeal neuroma is similar to that of ultrasonography. Imaging findings must be combined with clinical signs to make a diagnosis. Local closure with anesthetic can be used to help diagnosis, but the injection should be accurate, and the anesthetic should not be too much so as not to block the surrounding lesion tissue and affect the judgment. In the diagnosis, it should also be differentiated from the following diseases: lumbar disc herniation, tarsal tunnel syndrome, peripheral neuritis, synovitis of the metatarsophalangeal joints and metatarsophalangeal joint lesions caused by rheumatoid, gout, trauma, etc., metatarsal head necrosis, as well as the proximity of the synovial cysts, lipomas, tenosynovial cysts and so on. Wear loose, low-heeled shoes, add metatarsal pads on the proximal side of the affected area, and local closed injections (lidocaine and steroids) are feasible for those with unsatisfactory symptomatic relief. After 3-6 months of conservative treatment, most patients’ symptoms can be eliminated. To avoid local complications caused by hormones, continuous or multiple injections should not be used. When conservative treatment fails, surgical removal of the neuroma can completely eradicate it. Post-operative phenomena such as numbness or insensitivity in the area require a pre-operative statement.