It is possible, but relatively rare.
Most warts are caused by HPV-6 and/or HPV-11 infection, and such patients with low-risk HPV subtypes (i.e. low risk of associated cancers) infection rarely develop anogenital cancer; however, a small proportion of warts are caused by high-risk HPV infection (HPV 16 is most common, but can also be 18, 31, 33) or a combination of infections, and persistent high-risk HPV This condition is commonly seen in patients who are immunosuppressed (e.g. acquired immunodeficiency syndrome, organ transplant patients, patients taking immunosuppressive drugs such as hormones or immunosuppressants). In addition, giant condyloma acuminata are at greater risk of becoming cancerous.
Early detection and early treatment can prevent the progression of condyloma acuminatum to anogenital cancer.