1, for calcium antagonists “increased risk of heart disease”, mainly refers to cardiac pain. Studies have found that cardiac painkillers may increase blood pressure fluctuations, accelerate heart rate and increase target organ damage. Therefore, if you need to take cardioplegia for a long time, you should pay attention to monitoring and change the medication when necessary.
2. Since many calcium antagonists are metabolized in the liver and excreted by the kidney, patients with hepatic or renal insufficiency should not take too large a dose. Nimodipine mainly acts on cerebrovascular smooth muscle and has not been reported to cause “hepatitis”.
3, the U.S. Food and Drug Administration (FDA) on the valley/peak ratio of drugs: valley/peak ratio of more than 66% to meet the long-term antihypertensive requirements. The ratio is 30% to 50% for Boydin, 70% for Loxodren, and less than 30% for Cardiac Pain. Obviously, Boydin and Cardiac Pain are not suitable for long-term antihypertensive treatment.
4. Amlodipine is absorbed quickly orally, once a day, 5 mg each time, before and after meals. Individuals who experience dizziness and redness after taking the drug indicate that it is absorbed too quickly and can be taken after meals.
5. Although nifedipine and nimodipine are both calcium antagonists, their action sites are different. Nimodipine mainly dilates the cerebral blood vessels, which is beneficial to the recovery of brain function and cognitive function of stroke patients. Nifedipine mainly dilates the arteries of body circulation.
6.Long-term use of nifedipine controlled-release tablets affects about 5.9% of blood lipids, and triglycerides and cholesterol in blood will be increased.
7.Nifedipine is a short-acting calcium antagonist. It is absorbed quickly and blood pressure drops quickly, which can lead to reflex tachycardia and induce myocardial ischemia and acute vasodilation; and because of fast excretion, it needs to be taken several times a day and cannot inhibit the peak of cardiovascular events in the early morning. Therefore, it is not suitable for long-term use.
8, Luohuaxi belongs to the third generation of calcium antagonists, is a long-acting antihypertensive drugs, taking one tablet daily can control blood pressure for 24 hours, suitable for patients with mild to moderate hypertension. It does not cause myocardial infarction. But long-term use, pay attention to the presence of gum swelling and foot and ankle edema.
9, Verapamil is a non-dihydropyridine calcium antagonist, adverse effects include atrioventricular block and inhibition of cardiac function. For patients with bundle branch conduction block, a drug change should be considered. It can be changed to angiotensin II receptor antagonist (ARB) or calcium antagonist amlodipine.
10.Captopril should be avoided in combination with potassium-protective diuretics and potassium-replenishing agents, such as amisulpride, aminopterin, amiloride, potassium chloride, etc. When combined with other antihypertensive drugs, pay attention to the blood pressure should not be lowered too low.
11.Rotinexin is the trade name of Benadryl, which belongs to angiotensin converting enzyme inhibitor (ACEI) with Captopril. However, Captopril is a short-acting antihypertensive drug, while Lortin is a long-acting antihypertensive drug. Therefore, Captopril is often taken three times a day, while Lotensin can be taken once a day. Other rare side effects include angioneurotic edema, constipation, gastrointestinal discomfort, skin rash, and granulocytopenia. If no side effects occur, it can be used for a long time.
12.Esul generic name is Enalapril, one of the angiotensin converting enzyme inhibitors, which has good antihypertensive effect and protective effect on target organs such as heart, brain and kidney. But it also has certain side effects, commonly dry cough, and does not cause gout.
13.Devin is the trade name of valsartan, the side effects are less and lighter, occasionally headache, dizziness, gastrointestinal symptoms, skin rash, etc.. If there are no side effects, it can be used for a long time.
14.Diuretics commonly used are dihydrochlorothiazide, furosemide, amiloride, indapamide (Shoubisan) and spironolactone, etc.
15, Shoubishan (indapamide) is a long-acting diuretic antihypertensive drug with calcium antagonism, can be used alone for mild to moderate essential hypertension, but also in combination with other antihypertensive drugs. It can be started at 2.5 mg once daily. After that, it can be adjusted according to the blood pressure condition.
Sulbactam can be taken for a long time. A few patients may cause vertigo, headache, insomnia, drowsiness, nausea, diarrhea, and rash. Individual patients may cause elevated blood uric acid and even induce gout, and some may develop hypokalemia, so long-term use should be monitored. Allergy to sulfonamides, severe liver insufficiency, acute cerebrovascular accident patients should not be used.
16. Betalactam has side effects such as headache and eye pain. When you encounter this situation, you can stop taking Betalac first and try. If the eye pain disappears after stopping taking it for a while, and then the eye pain appears again after taking Betalac, it is related to Betalac. At this time, switch to angiotensin II receptor antagonist (ARB), angiotensin converting enzyme inhibitor (ACEI) or diuretic, etc. according to the condition.
17, compound rooibos is a compound preparation of Chinese and Western medicines, its ingredients include rooibos leaves, wild chrysanthemum, dihydralazine sulfate, hydrochlorothiazide and promethazine hydrochloride, etc.. Among them, hydrochlorothiazide may cause an increase in blood uric acid, so gout patients should not use compound rooibos. However, since the amount of hydrochlorothiazide contained in compound rooibos is not large, if the patient’s original uric acid is not high, it is not a big problem to take only 2 to 3 tablets a day. If you are worried, you can go to the hospital clinic to check the blood uric acid, not high, you can continue to take.
18.Jenju antihypertensive tablets are also a mixture of Chinese and Western medicines. Each tablet contains 30 micrograms of colistin, 5 mg of hydrochlorothiazide, and wild chrysanthemum, pearl layer, and acacia rice. It has the side effects of both diuretics and central antihypertensive drugs, and the adverse effects of taking the drug in large doses are related to the diuretics it contains. Patients with mild hypertension (blood pressure 140-150/90-100 mmHg) with dizziness and pain can try Zhenju antihypertensive tablets.
19.Lisperdal does not belong to the 6 basic antihypertensive drugs, but it can still be applied in view of the national situation. It has side effects such as nasal congestion (nasal congestion), mental depression, bradycardia and peptic ulcer. If there are no such side effects during the use, it can still be used for a long time.
In 2004, the prescription was adjusted to reduce the sedative component and renamed as “No. 0 Antihypertensive Tablet”. The main side effects of long-term use come from the side effects of blood pressure; because it contains the potassium-protecting diuretic aminopterin, it is important to pay attention to whether there is an increase in blood potassium.
21.Undecanine is a monooxygenase inhibitor, and its antihypertensive mechanism has not been fully elucidated. It is important to pay attention to postural hypotension and sometimes dry mouth, gastrointestinal discomfort, insomnia and dreaminess. This drug is generally used for moderate to severe hypertension. While taking this drug, you should not eat food containing cheese, otherwise pheochromocytoma-like attacks (sudden increase in blood pressure and twitching of limbs) may occur.
22, not all antihypertensive drugs will reduce sexual function. Some antihypertensive drugs also have a role in improving sexual function, such as valsartan (Dynavin). At present, it is believed that beta-blockers, diuretics (including Shoubisan), and eugenol may have some effect on sexual function, while angiotensin II receptor antagonists (ARB), angiotensin-converting enzyme inhibitors (ACEI), and alpha-blockers have less effect on sexual function.