Key points of the guidelines for the management of post-stroke epilepsy

  The 2014 Chinese guidelines on the management of acute ischemic stroke recommend ① Prophylactic application of antiepileptic drugs is not recommended (Class IV recommendation, Level D evidence); ② Long-term use of antiepileptic drugs is not recommended after one isolated seizure or acute phase seizure control (Class IV recommendation, Level D evidence); ③ For recurrent epilepsy 2-3 months after stroke, long-term drug treatment is recommended according to the conventional treatment of epilepsy (Class I recommendation, Level D evidence) ④ Persistent status epilepticus after stroke is recommended to be treated according to the principles of treatment of persistent status epilepticus (Class I recommendation, Level D evidence).  International guidelines 1. 2011 American Heart Association and American Stroke Association (AHA/ASA) Brain Hemorrhage Guidelines Recommendations for the management of epilepsy ① Patients with clinical seizures requiring antiepileptic treatment (Class I recommendation, Level A evidence); (Revised from the previous guideline) Antiepileptic treatment should be given (Grade III recommendation, Level C evidence); ③ Prophylactic antiepileptic treatment is not recommended (Grade II recommendation, Level B evidence); (New recommendation); ④ If epileptic seizures occur again 2 to 3 months after stroke, long-term drug treatment should be given according to the conventional treatment of epilepsy (Grade IV recommendation, Level D evidence).  2. 2009 AHA/ASA guidelines for the management of aneurysmal subarachnoid hemorrhage (SAH) regarding recommendations for epilepsy management ① More than 20% of patients with SAH have epilepsy, usually occurring within 24 h of bleeding; ② Anticonvulsants may be used prophylactically in patients in the hyperacute phase after SAH (Class IIb, Level B evidence).  (iii) Long-term use of anticonvulsants is not recommended (Class III, Level B evidence).  ④ However, anticonvulsants may be considered in patients with risk factors such as middle cerebral aneurysm, intraparenchymal hematoma, cerebral infarction, and history of hypertension (Class IIb, Level B evidence).