Tuberculous meningitis (referred to as tuberculosis) is a disease of the central nervous system caused by the invasion of Mycobacterium tuberculosis into the brain through the bloodstream or by other routes. The meninges are most commonly invaded, but the brain parenchyma, cerebral arteries, cerebral nerves, and spinal cord are also invaded, so there are four common clinical types: meningitis, intracerebral tuberculosis, cerebrospinal, and mixed. Because of the importance of the anatomical site of invasion, tuberculosis of the nodal brain is a serious disease. If treated early, with smooth medication and patient cooperation, a good prognosis can be achieved; however, late cases, with irrational treatment and difficult medication (such as drug-resistant cases, etc.), have a poor prognosis, leaving sequelae in severe cases and even death. Clinical manifestations 1.Early stage: Generally, the onset of the disease is slow, and most patients have intermittent headache, but it is tolerable, so they often do not consult the doctor or misdiagnose it as other causes of headache. At the same time, it may be accompanied by irregular low fever (37℃～38℃), night sweating, etc. The onset of the disease is within 2 weeks. 2. Middle stage: headache gradually increases, accompanied by vomiting, but without nausea, or in severe cases, jet vomiting. At the same time, the body temperature rises significantly, up to 38.5℃ or more, and the headache remains when the fever subsides. Pathological reflexes appear, cranial nerve disorder symptoms, most commonly motoneuropathy, diplopia, dilated pupils, etc., and even blindness. The meningeal irritation sign is positive, and this period usually lasts for two weeks. 3. Late stage: As the disease progresses, the patient develops consciousness disorder, from drowsiness to coma, and the deep and superficial reflexes disappear or form brain herniation until death. Some patients may experience limb paralysis, and unilateral limb paralysis or paraplegia, urinary and fecal incontinence, seizures, etc. may occur depending on the location of the lesion in the central nervous system. The prognosis is not good. 4. Chronic stage: unsuccessful treatment or non-systemic treatment, persistent high cranial pressure, headache, fever or long-term epilepsy, incontinence, etc. 5. Individual patients do not have the above-mentioned stages: only seizures, monoplegia or strabismus or olfactory abnormalities and other intracerebral focal manifestations of limited tuberculosis may prevail.