If the headache of gastroenteritis is severe, it may be related to the fever caused by gastroenteritis. It is recommended to improve the temperature check, if the temperature exceeds 38℃, antipyretic and analgesic drugs should be applied to control the symptoms. In case of gastrointestinal infection, routine blood tests should be done to clarify whether there is bacterial or viral infection. If the headache is combined with high blood count, it is recommended to apply anti-infective drugs, such as cephalosporins and quinolones, to treat the headache in a timely manner, and anti-inflammatory drugs such as cefixime, levofloxacin and norfloxacin can be chosen. If the pain is very serious, appropriate application of oral antipyretic and analgesic drugs, such as ibuprofen or santoprene tablets for treatment, and oral adjustment of the gastrointestinal tract drugs, such as Meclizine or omeprazole, can also play a very good effect.