Symptoms 1. In the same area, long-term topical corticosteroid use, skin dark spots; wrinkles; rosacea-like dermatitis; acne-like dermatitis; subcutaneous elastic fiber breakage leading to skin laxity; severe capillary dilation and diffuse expansion of tiny blood vessels. Especially in the case of hot and cold and other stimuli after the skin redness, itching, rising; increased sensitivity; premature aging; pore enlargement; abnormal increase in thickening of sweat hair and other phenomena. 2, after the formation of skin dependence, once the hormone products are discontinued, within 1-5 days, the lighter the phenomenon of desquamation, sensitivity, redness, swelling, itching, pain, etc.; the heavier the drug site skin fragility, tightness, skin occurrence of significant erythema, pigmentation, atrophy, atrophy lines, capillary dilation, papules, chaps, flakes, dry desquamation, small pustules, burning sensation, tenderness, strange itching and even The patient has to continue to resume the use of hormones, and the dependence on hormones is more obvious; when the product is used again, the above signs and symptoms will quickly subside. If the product is discontinued, the dermatitis symptoms will quickly reappear and gradually worsen, and the effect will decrease, so the amount of hormone used must be increased or replaced by stronger hormone products; 3. In serious cases, hormones can be absorbed into the blood circulation through the skin, causing medical diabetes, hypertension, osteoporosis, liver and kidney damage, obesity, menstrual disorders, and aggravation of existing cardiovascular disease in the elderly. Identifying signs: varying degrees of facial skin atrophy, thinning, shining, diffuse flushing or skin erythema, or capillary dilation, localized swelling, dryness and flaking, or acne-like rash or rosacea-like dermatitis or skin atrophy lines or folliculitis pustules. Symptoms: Self-perceived local itching, burning-like pain, tightness and swelling or dry discomfort, the above symptoms are aggravated by heat (such as sun exposure, hot bath, hot steam fumigation) and alleviated by cold. After discontinuation: the original disease aggravates after discontinuation of corticosteroids, while there are obvious hormone-dependent symptoms, that is, the condition improves rapidly after local application of corticosteroids, once discontinued, less than 1 to 2 days more than 3 to 5 days, more serious hormonal rebound dermatitis occurs than before, and even induces bacterial and fungal infections. Epidermal and dermal thinning local long-term topical hormone application, keratin-forming cell proliferation is inhibited. This leads to a reduction in the formation of hyaline keratin granules and eventually a thinning of the stratum corneum. Dermal thinning is due to the change of viscoelasticity of glycoproteins and proteoglycans, which weakens the adhesion between collagen protofibrils and reduces collagen synthesis, resulting in the thinning of epidermis due to the reduction of protein and lipid synthesis. Impaired epidermal barrier function leads to increased transepidermal water loss and increased sensitivity of the skin to external stimuli. Hypopigmentation/hyperpopigmentation is caused by a decrease in the number of layers of the stratum corneum and a decrease in the amount of melanin migrating to the keratin-forming cells. Hyperpigmentation may be associated with glucocorticoid activation of melanocytes to regenerate pigment. Vascular exposure due to weakened adhesion between collagen fibers in the vessel wall can lead to widening of the vessels and loss of dermal collagen resulting in surface vascularization. Acne vulgaris/acneiform dermatitis hormones can degenerate the epithelium of hair follicles, resulting in blocked outlets and acneiform rashes or aggravation of existing acne. Folliculitis infections can cause localized infected hair follicles to become infected and aggravate pre-existing folliculitis due to the immunosuppressive effects of hormones. Hormone dependence Hormones have powerful anti-inflammatory properties and can suppress many dermatological symptoms, such as inhibiting the development of papules and reducing itching, vasoconstriction, and disappearance of erythema. However, hormones cannot eliminate the cause of the disease and can often cause aggravation of the original disease after discontinuation, which can be seen as rebound phenomena such as inflammatory edema, redness, burning sensation, discomfort, and acute pustular rash. Side effects of hormone drugs There are many side effects of hormone topical drugs, the common ones are: Skin damage: 1. dark spots on the skin 2. wrinkles on the skin 3. rosacea-like dermatitis 4. acne-like dermatitis 5. skin laxity due to breakage of subcutaneous elastic fibers 6. severe capillary dilation (“red blood”) 7. diffuse dilation of tiny blood vessels, especially In the presence of hot and cold stimuli such as skin redness, itching, rise 8, increased skin sensitivity (both skin after the use of hormones, more prone to allergies) 9, premature skin aging 10, skin pore size 11, skin appears abnormal increase, thickening of the “sweat hair” 12, hormone-dependent dermatitis