Large vessels are the thickest arteries in the body, usually the thoracic and abdominal aorta. Once a lesion ruptures, the consequences can be catastrophic, so large vessel disease is also known as the “untimely bomb” in the body, and common diseases include thoracic aortic coarctation and abdominal aortic aneurysm. The common diseases include thoracic aortic coarctation and abdominal aortic aneurysm. The world is aware of “aortic coarctation”, a very dangerous large vessel disease. Aortic coarctation is one of the more common and most critical aortic disorders, manifested by blood flow breaking through the aortic intima into the intima, tearing the arterial wall into two inner and outer layers. The incidence in China is 20-50/100,000, which is twice as high as that in Europe and the United States, and the mortality rate is 33% in the first 24 hours, 50% in 48 hours, and more than 90% in 3 months if not treated. The cause of aortic coarctation is still unclear, but more than 80% of patients with aortic coarctation have hypertension, especially the middle-aged and elderly, which is more likely to lead to aortic coarctation. However, people who do not have high blood pressure should not take it lightly. Aortic coarctation can also be triggered by a momentary increase in blood pressure caused by excessive exercise, anger and rage, or even other factors. If you experience unexplained severe pain in the chest and back, you should seek medical attention.