The difference between positive and negative breast cancer is as follows: 1. The final treatment of breast cancer is now based on molecular typing. Molecular typing is divided into estrogen receptor positive and negative, let’s say estrogen receptor positive or estrogen negative treatment is not the same. If it is positive, endocrine therapy is required, which can be done by oophorectomy, ovarian suppression, direct use of triamcinolone or third generation aromatase inhibitors, which inhibit tumor growth by suppressing or blocking estrogen production, is a very good treatment process. If it is estrogen receptor negative, the patient usually needs to do chemotherapy. 2. Positive distinction usually refers to positive and negative lymph nodes, that is, whether the lymph nodes have metastasis or not, and often you can see pathology report sheets talking about positive lymph nodes. In case of positive lymph nodes, the axillary lymph nodes need to be cleared during surgery, and according to the number of metastases in the axillary lymph nodes cleared, it is decided whether to do the corresponding radiation therapy after breast cancer surgery. However, if the lymph nodes are negative, the patient does not need to do lymph node dissection, and only a simple anterior lymph node biopsy can be done. 3. Clinical overexpression of HER2 gene can be seen, and some patients are also understood as positive and negative. If HER2 gene overexpression, usually patients often say positive situation, need to do a year of targeted therapy, there are single target, double target. If negative, there is no need to have targeted therapy for HER2 positive drugs, chemotherapy or endocrine therapy is fine.