79-year-old Chen has been suffering from rheumatoid arthritis for more than 30 years. For more than 30 years, Chen has been suffering from the disease, accompanied by her children to seek medical treatment everywhere, but felt that the effect was not good, and finally listened to the so-called “secret formula” sent outside, after taking it, the joint pain was temporarily stopped, but the deformity of the hand and foot joints worsened, and her body deteriorated. Due to the torture of the disease, she lost her confidence in life. Recently, she was admitted to the rheumatology ward with the insistence of her children because she had been bedridden with back pain for several months. Physical examination revealed that her hands and feet joints had been severely deformed, the ends of her toes were purple, the ends of her left toes were ulcerated, the third toe of her left foot was missing, and there was severe osteoporosis with compression fractures of the thoracic vertebrae. After further examination, the right thoracic cavity was found to be filled with pus, and the bacterial culture was Pseudomonas aeruginosa. The condition was complicated and critical, and after hospitalization, the Department of Rheumatology and Immunology formulated a treatment plan after several discussions within the department, and cooperated with the Department of Respiratory Medicine. Although rheumatoid arthritis is an autoimmune disease, it cannot be cured yet, but if detected early and treated regularly, most of them can be well controlled and stabilized, and with the listing of biologics in recent years, especially in the early stage of the disease, biologics combined with traditional slow-acting drugs can achieve better treatment results. It is sad to see that there are few people like Granny Chen who did not receive regular treatment in the early stage of the disease, resulting in serious deformity and osteoporosis, secondary infection, etc. They often listen to the so-called “bias” “secret formula”, delaying the treatment and losing the other The best time for treatment is lost. In fact, rheumatoid arthritis is not terrible, the key is early diagnosis and early formal treatment. Rheumatic diseases as a large group of pain and swelling of the skeletal and muscular system as the prominent manifestation of the clinical disease, in China’s traditional medicine has been recorded for a long time, called “paralysis”. However, modern rheumatology, based on immunology, started later in China, and rheumatology and immunology, as a new medical specialty, did not develop gradually in China until the last two decades, so to speak. Today, although the etiology and pathogenesis of many rheumatic diseases are still unclear, with the continuous in-depth research on basic immunology related to rheumatic diseases, many new results have been achieved, which greatly promote the level of diagnosis and treatment of rheumatic diseases to a new level, and the basic and clinical development of rheumatic immunology discipline has been rapid. The prognosis of some rheumatic diseases such as systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, and gout has improved greatly, which can be attributed to the diagnosis and active treatment at the early stage of the disease, the improvement of treatment measures, and the improvement of medical conditions. In recent years, magnetic resonance imaging (MRI), spiral CT, and nuclear imaging (ECT) have been commonly used in clinical practice, but the clinical use of ultrasonography in the skeletal and muscular system as a more inexpensive and less physically damaging imaging test has been gaining more and more attention from rheumatologists. The Department of Rheumatology and Immunology of Ningbo No. 2 Hospital has recently developed a new method for the assessment of bone, cartilage, synovial, tendon and ligament lesions. The Department of Rheumatology and Immunology of Ningbo Second Hospital will introduce joint ultrasound in the near future to improve the early diagnosis of various types of arthritis, determine the disease activity, and evaluate the treatment effect and prognosis. In addition, the Department of Rheumatology and Immunology has set up a joint clinic with the Department of Orthopedics, relying on the Joint Disease Center of the Second Hospital, to achieve better treatment results through orthopedic arthroscopic treatment and surgical treatment.