Step 1: Diagnosis of Parkinson’s syndrome Decreased motor activity: slow onset of random movements and gradual decrease in speed and amplitude of repetitive movements with at least one of the following symptoms: 1. muscle tonus; 2. resting tremor (4-6 Hz); 3. upright instability (not caused by primary visual, vestibular, cerebellar and proprioceptive dysfunction). Step 2: Parkinson’s disease exclusion criteria history of recurrent stroke with stepwise progression of Parkinson’s symptoms; history of recurrent brain injury; definite history of encephalitis; motility crisis; being treated with neuroleptics at the time of symptom onset; more than 1 relative with the disease; persistent remission; strictly unilateral involvement three years after onset; supranuclear gaze palsy; cerebellar signs; early onset of severe autonomic involvement; early onset of severe dementia with memory, language and behavioral deficits; positive pyramidal fasciculus sign (Babinski’s sign +); intracranial tumor or traffic hydrocephalus visible on CT scan; ineffective treatment with high doses of levodopa (except for impaired absorption); history of MPTP exposure to an opioid analgesic derivative. Step 3: Supporting diagnostic criteria for Parkinson’s disease. The diagnosis of Parkinson’s disease is confirmed by having three or more unilateral onset; presence of resting tremor; progressive disease progression; persistent asymmetry of symptoms, with the first side being more severe; very good response to levodopa treatment (70-100%); severe isokinetic disorder due to levodopa application; persistent effect of levodopa treatment for more than 5 years (including 5 years); clinical course of the disease for more than 10 years (including 10 years); meeting the first step The diagnosis of Parkinson’s disease is clinically confirmed in patients who do not have any of the diagnostic criteria of the second step and who also meet three or more of the third step.