Unlike other orthopedic surgeries, arthroplasty is characterized by strong postoperative pain, especially in total knee arthroplasty. Postoperative pain affects patient satisfaction and recovery of postoperative joint function, and also leads to an increase in complications. Therefore, postoperative pain control after total knee arthroplasty is particularly important. Current analgesic treatments tend to focus on a single aspect or drug application, or only on postoperative treatment. Postoperative pain after total knee replacement is multifactorial and multilayered, and improper handling of any part of the preoperative, intraoperative and postoperative process will affect the effect of postoperative analgesia. Postoperative pain control should be carried out throughout the perioperative period. Cyclooxygenase inhibitors are routinely used in the preoperative period for preventive hyperalgesia. During the operation, the self-developed “cocktail injection method” (ropivacaine hydrochloride, morphine hydrochloride, Depo-Proxon, epinephrine) was used for periarticular injection of analgesia, and the intraoperative treatments included reducing the time of tourniquet use during the operation, using cold saline to pulse rinse, avoiding soft tissue compression when installing prosthesis, and using electric knife to iron the patella after patellar shaping. After patellofemoral shaping, the peripatellar soft tissues were denervated with an electric knife, and care was taken not to suture the suprapatellar bursa to the patellar tendon when closing the wound. Postoperatively, the peripatellar soft tissue was denervated with electrocautery, and care should be taken not to suture the suprapatellar bursa to the patellar tendon during wound closure. Through the comprehensive treatment of preoperative, intraoperative and postoperative, most of the patients with total knee replacement have very little or no postoperative pain, which is very popular among the patients. Postoperative pain in total knee arthroplasty is multifactorial and multilayered. The prevention of pain should include both physical and psychological treatments. The concept of hyperalgesia should be carried out throughout the perioperative period and be emphasized in different periods of preoperative, intraoperative and postoperative. It emphasizes the synergistic effect of multiple drugs in different aspects to improve the analgesic effect and reduce the side effects of drugs. With intraoperative periarticular multimodal drug injection and the improvement of surgical techniques. In this way, postoperative pain can be effectively controlled, complications can be reduced, recovery of joint function can be accelerated, and patient satisfaction can be improved.