Endometrial thickening is often classified as physiological endometrial thickening and pathological endometrial thickening, which are usually associated with menstruation, endometrial hyperplasia, endometrial cancer and other factors. In clinical practice, there are some differences in the treatment for different endometrial thickening: a. Physiological endometrial thickening: for patients before menstruation, after pregnancy and during perimenopause, a certain degree of endometrial thickening may occur due to the influence of estrogen and progesterone in the body, which is mostly a normal physiological phenomenon, so there is no need to worry too much and usually no treatment is needed. The endometrial thickening is mostly due to endometrial hyperplasia, endometrial cancer and other disease factors that lead to thick endometrium, which is mainly treated by medication and surgery. 1, medication: (1) progesterone drugs: medroxyprogesterone acetate, progesterone, levonorgestrel, dydrogesterone, etc., which can be administered orally or intramuscularly, which can transform the thickened endometrium into normal endometrium through medication; (2) Gonadotropin-releasing hormone analogues: mostly used for those whose progestin therapy is ineffective or contraindicated by progestin therapy, such as abnormal liver function and obesity, and can be used alone or in combination with intrauterine device systems containing levonorgestrel or aromatase inhibitors.2. Surgical treatment: (1) Diagnostic scraping: this is a common diagnostic method and treatment means, and local lesions are scraped and aspirated to achieve diagnostic clearance. (2) Hysterectomy: for patients with endometrial hyperplastic lesions developing toward endometrial cancer and who are ineffective to drug treatment, relapse after stopping drug, older than 40 years old and without fertility requirements, they can be treated by hysterectomy; (3) Endometrial ablation: physical methods are used to destroy the endometrium but preserve the uterus, such as irreversible destruction of the endometrium with radiofrequency energy. This method can be considered for the treatment of patients who have a thick endometrium but no need for fertility.